fifteen grams every day regarding dietary K + intake sustained to own 20 days (20, 43). Latest conclusions (chatted about less than) keeps understood the existence of an enthusiastic enteric K + sensing apparatus one to initiates this new kidney secretory techniques on K + admission into digestion. This new distal convoluted tubule has been recognized as a site important to possess K + homeostasis, where they acts as good K + sensor with the capacity of establishing K + removal separate from mineralocorticoid craft.
Article on Kidney K + Dealing with
K + was freely blocked over the glomerulus following avidly reabsorbed by the the fresh proximal tubule and you can thicker rising limb of one’s kidney. K + reabsorption regarding proximal tubule is especially from the paracellular pathway that is within the crude ratio on amount of Na + and liquids reabsorbed (Fig. 1). On thicker ascending limb, K + reabsorption occurs by the both transcellular and you may paracellular routes. Transcellular way is actually mediated of the Na + -K + -2Cl ? cotransporter on the apical membrane layer. A component of K + that goes into the new cell straight back diffuses towards the lumen through the ROMK (kidney external medullary K + ) station, resulting in the fresh new age bracket regarding a beneficial lumen confident charges hence, in turn, drives a component of K + reabsorption from paracellular pathway (Fig. 2).
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